Title :
Conformal ceramic electrodes that record glutamate release and corresponding neural activity in primate prefrontal cortex
Author :
Hampson, R.E. ; Fuqua, Joshua L. ; Huettl, Peter F. ; Opris, I. ; Dong Song ; Dae Shin ; Marmarelis, V.Z. ; Berger, Theodore W. ; Gerhardt, Greg A. ; Deadwyler, S.A.
Author_Institution :
Dept. of Physiol., Wake Forest Sch. of Med., Winston-Salem, NC, USA
Abstract :
Conformal ceramic electrodes utilized in prior recordings of nonhuman primate prefrontal cortical layer 2/3 and layer 5 neurons were used in this study to record tonic glutamate concentration and transient release in layer 2/3 PFC. Tonic glutamate concentration increased in the Match (decision) phase of a visual delayed-match-to-sample (DMS) task, while increased transient glutamate release occurred in the Sample (encoding) phase of the task. Further, spatial vs. object-oriented DMS trials evoked differential changes in glutamate concentration. Thus the same conformal recording electrodes were capable of electrophysiological and electrochemical recording, and revealed similar evidence of neural processing in layers 2/3 and layer 5 during cognitive processing in a behavioral task.
Keywords :
bioceramics; bioelectric potentials; biomedical electrodes; molecular biophysics; neurophysiology; proteins; behavioral task; cognitive processing; conformal ceramic electrodes; electrochemical recording; electrophysiological recording; glutamate release recording; glutamate transient release; match decision phase; neural activity; neural processing; nonhuman primate prefrontal cortical layer; sample encoding phase; tonic glutamate concentration; visual delayed-match-to-sample task; Animals; Ceramics; Delays; Educational institutions; Microelectrodes; Neurons;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6610908
