Title :
A microsieve for leukocyte depletion of erythrocyte concentrates
Author :
van Rijn, Cees ; Nijdam, Wietze ; Elwenspoek, Miko
Author_Institution :
MESA Res. Inst., Twente Univ., Enschede, Netherlands
fDate :
31 Oct-3 Nov 1996
Abstract :
A new ultra thin filtration membrane has been used for leukocyte removal from erythrocyte concentrates. This filtration membrane, an Aquamarijn Microsieve(R), has a high pore density and a narrow pore size distribution and shows good separation behaviour. The low surface roughness of the microsieve will contribute to the biocompatibility and will reduce cell rupture, in particular hemolysis, during filtration. In this paper a brief overview of the effects that occur during filtration will be given. Also the results of the experiments of leukocyte removal from erythrocyte concentrates will be discussed
Keywords :
biological techniques; biomedical equipment; blood; cellular biophysics; filtration; membranes; micromachining; micromechanical devices; porosity; separation; Aquamarijn Microsieve; biocompatibility; erythrocyte concentrates; hemolysis; high pore density; leukocyte depletion; leukocyte removal; low surface roughness; micromachined sieve; microsieve; narrow pore size distribution; reduced cell rupture; separation behaviour; ultrathin filtration membrane; Biomembranes; Cells (biology); Dry etching; Filters; Filtration; Rough surfaces; Silicon; Surface roughness; Testing; White blood cells;
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.656941
