Title :
A circuit model for Bio-chemical Cell signaling receptor protein and phosphorylation cascade pathway
Author :
Hasan, S. M Rezaul
Author_Institution :
Center for Res. in Analog & VLSI Microsyst. dEsign (CRAVE), Massey Univ., Auckland, New Zealand
Abstract :
Communication between cells in multicellular organisms such as animals, humans and plants is essential for co-ordinating the organismic activities of fertilization, growth, survival and reproduction. This bio-chemical communication between trillions of cells in organisms can be more complex than the Internet. This paper develops a CMOS circuit model of signal reception and signal transduction within a cell in response to extra-cellular molecular signals. The model converts the chemical signaling pathway into a CMOS multi-step logical transformation cascade. This modeling technique leads to understanding cellular malfunctions (diseases) in the form of logical (electrical) faults in a circuit.
Keywords :
CMOS integrated circuits; CMOS logic circuits; biochemistry; cellular biophysics; electrical faults; integrated circuit modelling; molecular biophysics; physiological models; proteins; CMOS circuit model; CMOS multistep logical transformation cascade; biochemical cell signaling; biochemical communication; cellular malfunctions; chemical signaling pathway; diseases; electrical faults; extracellular molecular signals; fertilization; growth; logical faults; multicellular organisms; organismic activities; phosphorylation cascade pathway; receptor protein; reproduction; signal reception; signal transduction; survival; Biochemistry; Biological system modeling; Integrated circuit modeling; Organisms; Protein engineering; Relays; Semiconductor device modeling; Signal processing; Systems biology; Very large scale integration; ATP; G-protein; Systems biology; analog CMOS; phosphorylation cascade;
Conference_Titel :
Microelectronics, 2008. ICM 2008. International Conference on
Conference_Location :
Sharjah
Print_ISBN :
978-1-4244-2369-9
Electronic_ISBN :
978-1-4244-2370-5
DOI :
10.1109/ICM.2008.5393542
