Surface modification of a polymeric contrast agent for cancer targeting

Author

Leodore, Lauren M. ; Oum, Kelleny L. ; Lathia, Justin D. ; Wheatley, Margaret A.

Author_Institution

Sch. of Biomed. Eng., Drexel Univ., Philadelphia, PA, USA

fYear

2005

fDate

2-3 April 2005

Firstpage

142

Lastpage

143

Abstract

In order to develop a targeted contrast agent that enhances ultrasound images, polylactic acid (PLA) microcapsules were coated with fibronectin peptide sequences. The microcapsules were coated with either GRGDS or REDV peptide sequences that target integrins expressed in angiogensis, α_vβ₃ and α_vβ₅. Preliminary in vitro (static and flow regimes) results indicate that the modified capsules remain highly echogenic and adhere to the breast cancer cell line MDA-MB-231 as opposed to unmodified control capsules. Specific targeting of ultrasound contrast agents could be used as a means of targeted imaging for tumor cells and potentially as a drug delivery vehicle.

Keywords

biochemistry; biological organs; biomedical ultrasonics; cancer; cellular biophysics; drugs; gynaecology; image enhancement; molecular biophysics; polymers; proteins; tumours; Arg-Glu-Asp-Val peptide sequence; Gly-Arg-Gly-Asp-Ser peptide sequence; MDA-MB-231; angiogensis; breast cancer cell line; cancer targeting; drug delivery vehicle; fibronectin peptide sequence; polylactic acid microcapsule; polymeric contrast agent; surface modification; ultrasound contrast agent; ultrasound image enhancement; unmodified control capsule; Breast cancer; Drug delivery; In vitro; Peptides; Polymers; Programmable logic arrays; Sequences; Tumors; Ultrasonic imaging; Vehicles;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2005. Proceedings of the IEEE 31st Annual Northeast

Print_ISBN

0-7803-9105-5

Electronic_ISBN

0-7803-9106-3

Type

conf

DOI

10.1109/NEBC.2005.1431964

Filename

1431964