Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model

Author

Shi, William T. ; Porter, Thomas R. ; Vignon, Francois ; Powers, Jeffry E. ; Gao, Shunji ; Liu, Jinjin ; Xie, Feng ; Drvol, Lucas ; Lof, John ; Everbach, E. Carr

Author_Institution

Philips Res. North America, Briarcliff Manor, NY, USA

fYear

2011

fDate

18-21 Oct. 2011

Firstpage

5

Lastpage

8

Abstract

Image-guided sonothrombolysis was prototyped on a modified ultrasound imaging system iE33 and further evaluated using a porcine acute ischemic stroke model. After 20 to 40 minute sonothrombolysis treatment with systemic infusion of Definity microbubbles, contrast reperfusion and arterial recanalization were observed on low MI ultrasound contrast imaging and X-ray based angiography, respectively. The study indicates that a modified diagnostic imaging system can be utilized with systemic microbubble infusion to rapidly restore cerebral blood flow in acute ischemic stroke.

Keywords

biomedical ultrasonics; blood vessels; bubbles; diagnostic radiography; diseases; haemodynamics; haemorheology; image sequences; medical image processing; X-ray based angiography; arterial recanalization; cerebral blood flow restoration; contrast reperfusion; definity microbubble systemic infusion; image sequence; image-guided sonothrombolysis; low MI ultrasound contrast imaging; modified ultrasound imaging system iE33; porcine acute ischemic stroke model; time 20 min to 40 min; Acoustics; Attenuation; Biomedical imaging; Bones; Integrated circuits; Ultrasonic imaging; cavitation; microbubbles; sonothrombolysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2011 IEEE International

Conference_Location

Orlando, FL

ISSN

1948-5719

Print_ISBN

978-1-4577-1253-1

Type

conf

DOI

10.1109/ULTSYM.2011.0002

Filename

6293205