Title :
Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model
Author :
Shi, William T. ; Porter, Thomas R. ; Vignon, Francois ; Powers, Jeffry E. ; Gao, Shunji ; Liu, Jinjin ; Xie, Feng ; Drvol, Lucas ; Lof, John ; Everbach, E. Carr
Author_Institution :
Philips Res. North America, Briarcliff Manor, NY, USA
Abstract :
Image-guided sonothrombolysis was prototyped on a modified ultrasound imaging system iE33 and further evaluated using a porcine acute ischemic stroke model. After 20 to 40 minute sonothrombolysis treatment with systemic infusion of Definity microbubbles, contrast reperfusion and arterial recanalization were observed on low MI ultrasound contrast imaging and X-ray based angiography, respectively. The study indicates that a modified diagnostic imaging system can be utilized with systemic microbubble infusion to rapidly restore cerebral blood flow in acute ischemic stroke.
Keywords :
biomedical ultrasonics; blood vessels; bubbles; diagnostic radiography; diseases; haemodynamics; haemorheology; image sequences; medical image processing; X-ray based angiography; arterial recanalization; cerebral blood flow restoration; contrast reperfusion; definity microbubble systemic infusion; image sequence; image-guided sonothrombolysis; low MI ultrasound contrast imaging; modified ultrasound imaging system iE33; porcine acute ischemic stroke model; time 20 min to 40 min; Acoustics; Attenuation; Biomedical imaging; Bones; Integrated circuits; Ultrasonic imaging; cavitation; microbubbles; sonothrombolysis;
Conference_Titel :
Ultrasonics Symposium (IUS), 2011 IEEE International
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-4577-1253-1
DOI :
10.1109/ULTSYM.2011.0002
