A programmable biomolecular computing devices with RNAi

The main advantage of biomolecular computing devices in vivo is their ability to interact directly with biological systems. All components of the molecular computers, including the input module, computation module and output module are molecules that interact in solution along a cascade of programmable chemical events. Here, a biomolecular computing model in vivo for SAT problem is presented. A synthetic gene network is constructed by RNAi and lactose operon in living cell. This model explores further the ability to solve hard problems based on organism processing signal.