Nanotechnology enabled platforms for trace detection of pharmaceuticals

Author

Annam, Venkata Praveen ; Mertz, Timothy O. ; Vattipalli, Krishna ; Nagaraj, Vinay ; Prasad, Shalini

Author_Institution

Dept. of Electr. Eng. & Comput. Sci., Wichita State Univ., Wichita, KS, USA

fYear

2011

fDate

15-18 Aug. 2011

Firstpage

1619

Lastpage

1623

Abstract

The current research leverages a nanotechnology enabled sensor platform for highly sensitive detection of pharmaceuticals contaminants in water samples using electrochemical impedance spectroscopy. The sensor surface consists of lithographically patterned gold electrodes and is functionalized with anti-pharmaceutical antibodies. A nanoporous alumina membrane is placed over the sensor surface to achieve enhanced signal amplification. Erythromycin and Ibuprofen were successfully detected on the sensor in amounts as low as parts per quadrillion. The design has potential to be developed into portable diagnostic equipment, offering rapid, inexpensive and highly reliable detection of pharmaceuticals with applications in the assessment of water quality.

Keywords

contamination; drugs; electrochemical impedance spectroscopy; electrochemical sensors; industrial waste; nanosensors; water pollution measurement; water quality; antipharmaceutical antibodies; electrochemical impedance spectroscopy; erythromycin; ibuprofen; lithographically patterned gold electrodes; nanoporous alumina membranes; nanotechnology enabled sensor platform; pharmaceuticals contaminants detection; pharmaceuticals trace detection; portable diagnostic equipment; signal amplification enhancement; water quality assessment; Capacitance; Electrodes; Impedance; Impedance measurement; Pharmaceuticals; Rivers; Surface impedance;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology (IEEE-NANO), 2011 11th IEEE Conference on

Conference_Location

Portland, OR

ISSN

1944-9399

Print_ISBN

978-1-4577-1514-3

Electronic_ISBN

1944-9399

Type

conf

DOI

10.1109/NANO.2011.6144466

Filename

6144466