Title :
On modeling electric fields for microscale cell manipulation
Author :
Avdeev, Ilya V. ; Lovell, Michael R.
Author_Institution :
Univ. of Wisconsin-Milwaukee, Milwaukee, WI, USA
Abstract :
Strongly-coupled finite element analysis is applied to modeling micromachined devices designed for biological cell manipulation. Nonuniform, fringing three-dimensional electric fields in heterogeneous media are accurately represented by finite element models. Cell manipulation by dielectrophoresis and direct contact and is discussed in detail. Two design cases are studied using the developed finite element methodology: a DEP cell sorter and a micro stage device for cell stretching. Results of the simulation agree with the experimental observations reported in the literature.
Keywords :
bioMEMS; bioelectric phenomena; biological techniques; biomechanics; cellular biophysics; electric field effects; electrophoresis; electrostatics; finite element analysis; micromachining; DEP cell sorter; biological cell manipulation; cell stretching; dielectrophoresis; electric field modeling; heterogeneous media; micromachined device modeling; microscale cell manipulation; microstage device; nonuniform fringing 3D electric fields; strongly-coupled finite element analysis; Biological cells; Biological system modeling; Cells (biology); Dielectrophoresis; Electrostatics; Finite element methods; Micromechanical devices; Nonuniform electric fields; Polarization; Transducers; cell manipulation; dielectrophoresis; finite element method;
Conference_Titel :
Information Technology and Applications in Biomedicine, 2009. ITAB 2009. 9th International Conference on
Conference_Location :
Larnaca
Print_ISBN :
978-1-4244-5379-5
Electronic_ISBN :
978-1-4244-5379-5
DOI :
10.1109/ITAB.2009.5394383
