DocumentCode :
3228159
Title :
Precise transportation of single cell by phase-shift standing surface acoustic wave
Author :
Meng, Long ; Cai, Feiyan ; Jin, Qiaofeng ; Niu, Lili ; Hairong Zhen
Author_Institution :
SIAT, Paul C. Lauterbur Res. Center for Biomed. Imaging, Shenzhen, China
fYear :
2011
fDate :
18-21 Oct. 2011
Firstpage :
1304
Lastpage :
1307
Abstract :
Precise transportation of bioparticles has become an increasingly important technique for numerous lab-on-a-chip bioengineering researches and applications, including cell fusion, gene transfection, and blood separation. In this paper, we develop a microfluidic device combination a SAW device and a PDMS microchannel to precisely transport the single cell. When the single cell suspended in standing wave field, the cell would be retained in the pressure nodes. By introducing a phase-shift to standing surface acoustic wave (SSAW), the translation of pressure nodes in the standing wave field results in the transportation of the single cell. The experimental results reveal that there is a good linear relationship between the relative phase and the displacement. This technique has its distinct advantages, such as precise position-manipulation, simple to implement, miniature size, and noninvasive character, which may provide an effective method for the position-manipulation of a single cell in many biological and biomedical applications.
Keywords :
bioMEMS; biomedical engineering; cellular transport; microfluidics; polymers; surface acoustic waves; suspensions; PDMS microchannel; SAW device; biological application; biomedical application; bioparticle precise transportation; blood separation; cell fusion; gene transfection; microfluidic device combination; miniature size; noninvasive character; numerous lab-on-a-chip bioengineering researches; phase-shift standing surface acoustic wave; precise position-manipulation; pressure node translation; single cell position-manipulation; single cell suspension; single cell transportation; standing wave field; Microchannel; Microfluidics; Optical surface waves; Surface acoustic waves; Transportation; Acoustic manipulation; Microfluidic; Single cell; Surface acoustic wave;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium (IUS), 2011 IEEE International
Conference_Location :
Orlando, FL
ISSN :
1948-5719
Print_ISBN :
978-1-4577-1253-1
Type :
conf
DOI :
10.1109/ULTSYM.2011.0322
Filename :
6293313
Link To Document :
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