Title :
Ligand doping of iron oxide nanoparticles as an approach to novel oral iron therapeutics
Author :
Faria, Nuno ; Pereira, Dora ; Mergler, Bianca ; Powell, Jonathan
Author_Institution :
Dept. of Cellular & Mol. Sci., MRC-HNR Elsie Widdowson Lab., Cambridge, UK
Abstract :
We report on (a) a novel procedure to dope ferric oxide primary particles with GRAS ligands (b) their characterization and stability in cell culture solution (c) their uptake and utilization by gut cells in culture and (d) their delivery to human volunteers. Overall, these materials are cheap to manufacture and show promise for safe and efficient oral iron delivery to help ease the global burden of iron deficiency anemia.
Keywords :
cellular biophysics; diseases; drugs; iron compounds; molecular biophysics; nanomedicine; nanoparticles; Fe2O3; GRAS ligands; cell culture solution; gut cells; iron deficiency anemia; iron oxide nanoparticle ligand doping; ligand doped ferric oxide primary particles; oral iron therapeutics; Absorption; Doping; Humans; Iron; Materials; Nanoparticles; Proteins;
Conference_Titel :
Nanotechnology (IEEE-NANO), 2011 11th IEEE Conference on
Conference_Location :
Portland, OR
Print_ISBN :
978-1-4577-1514-3
Electronic_ISBN :
1944-9399
DOI :
10.1109/NANO.2011.6144520
