Title :
Genome-wide alternative splicing events detection through analysis of large scale ESTs
Author :
Hsu, F.R. ; Chang, Hwan-You ; Lin, Yaw-Lin ; Tsai, Yin-Te ; Peng, Hui-Ling ; Chen, Ying Tsong ; Chen, Che Feng ; Cheng, Chia Yang ; Liu, Chia-Hung ; Shih, Min Yao
Author_Institution :
Dept. of Inf. Technol., Taichung Healthcare & Manage. Univ., Taiwan
Abstract :
In the past several years, the analysis of alternative splicing and its application to identify the origins of disease has been gaining momentum. Therefore, we developed a value added transcriptome database (Avatar). We mapped EST (expressed sequence tag) and mRNA sequences onto whole human genomic sequence. We identified 9,937 alternative splicing relationships genes through an analysis of large-scale ESTs. Besides, we provided alternative splicing information for six organisms: Homo sapiens, Mus musculus, Rattus norvegiens, Caenorhabditis elegans, Drosophila melanogaster and Arabidopsis thaliana.
Keywords :
biology computing; genetics; medical computing; sequences; Arabidopsis thaliana; Avatar; Caenorhabditis elegans; Drosophila melanogaster; EST; Homo sapiens; Mus musculus; Rattus norvegiens; alternative splicing events detection; expressed sequence tag; genome; mRNA sequences; transcriptome database; Avatars; Bioinformatics; Databases; Diseases; Event detection; Genomics; Humans; Large-scale systems; Organisms; Splicing;
Conference_Titel :
Bioinformatics and Bioengineering, 2004. BIBE 2004. Proceedings. Fourth IEEE Symposium on
Print_ISBN :
0-7695-2173-8
DOI :
10.1109/BIBE.2004.1317358
