Bio-manipulation probe integration with micro-force sensor

Author

Wenming, Xi ; Hui, Zhong

Author_Institution

Dept. of Mech. Eng., Xiamen Univ., Xiamen

fYear

2008

fDate

6-9 Jan. 2008

Firstpage

393

Lastpage

396

Abstract

In bio-manipulation, a micro-force sensor is demanded to control operation force, specially in cells injection. In this paper, a PVDF membrane is used to design micro-force sensor, this membrane is integrated with bio-manipulation probe, in this way, the micro-force sensor can control cells injection and bio-manipulation. In order to measure spring constant of membrane, a resonance frequency method is used. After spring constant of membrane is obtained, the nano-platform can be used to calibrate the relation of pressed force and output volt of membrane. Our experiment results show that the resonance frequency method can measure the spring constant of membrane accurately. In this paper, the spring constant of our micro-force sensor is 4.4 muN/mum, the minimum force that micro-force sensor can measure is 44 muN.

Keywords

biosensors; cellular biophysics; force sensors; microsensors; PVDF membrane; biomanipulation probe integration; cells injection; microforce sensor; operation force; resonance frequency; spring constant; Biomembranes; Biosensors; Force control; Force measurement; Force sensors; Frequency measurement; Probes; Resonance; Resonant frequency; Springs; Micro-Force Sensor; PVDF Membrane; Resonance Frequency; Spring constant of Membrane;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems, 2008. NEMS 2008. 3rd IEEE International Conference on

Conference_Location

Sanya

Print_ISBN

978-1-4244-1907-4

Electronic_ISBN

978-1-4244-1908-1

Type

conf

DOI

10.1109/NEMS.2008.4484357

Filename

4484357