Simultaneous temperature and cavitation activity mapping

Ultrasound therapies utilize mechanical and/or thermal effects induced by the interaction of highly focused ultrasonic waves with tissues for the development of novel therapeutic approaches. Here, we present a dual modality approach (MR and US) that allows simultaneous MR thermometry and passive ultrasonography. Multi-parametric images that display simultaneous temperature elevation and cavitation activity are subsequently used to assess with high spatiotemporal accuracy both mechanical (cavitation) and thermal effects of FUS. It is believed that this approach will enable the development of comprehensive FUS treatment i) planning, ii) monitoring and iii) confirmation for safe and efficacious therapies.