Particularities of tissue types in treatment planning of nano cryosurgery

The aim of the recently proposed nano cryosurgery is to exactly kill all tumor cells within the target region, which is defined by the characters of the tissues, such as bulk feature, shape, type and so on. It is easy to see that nano particles play a very critical role in cryosurgery. However, the amounts of nano particles could be loaded generally differ significantly due to variation of different tissue structures. This is particularly true for tumors situated at or surrounding some important organs. Therefore, treatment planning and understanding tissue temperature responses during a nano cryosurgery is rather important for the success of such innovated therapy. This study is dedicated to evaluate the temperature responses of different tissue types when subjected to cryosurgery by adjuvant use of nano particles. It was shown that for each organ, individuation must be considered for controlling the cooling dose in a nano cryosurgery in order to avoiding negative effect. Mechanisms coming from the diverse porosity, water content, density, blood perfusion, thermal conductivity, specific heat, and so on for each tissue were preliminarily interpreted.