Integrated flow sensing for focal biochemical stimulation

Author

Chang, Li-Yuan ; Li, Po-Ying ; Zhao, Lingyun ; Hoang, Tuan ; Meng, Ellis

Author_Institution

Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA

fYear

2008

fDate

6-9 Jan. 2008

Firstpage

921

Lastpage

926

Abstract

A microfluidic platform for focal stimulation of cells and tissue allows precise biochemical control of the extracellular microenvironment. This interface consists of a polymer microchannel having a single pore through which chemicals are selectively diffused or ejected. Towards the realization of realtime feedback control of focal biochemical stimulation, integrated thermal flow sensors were used to monitor fluid release. Delivery of fluorescent dye to rat retina is also presented.

Keywords

biosensors; chemical sensors; flow sensors; microfluidics; microsensors; temperature sensors; biochemical control; cell focal stimulation; extracellular microenvironment; flow sensing; fluorescent dye; focal biochemical stimulation; microfluidic platform; ntegrated flow sensing; polymer microchannel; rat retina; thermal flow sensors; tissue focal stimulation; Biosensors; Chemical and biological sensors; Extracellular; Feedback control; Fluid flow control; Microchannel; Microfluidics; Monitoring; Polymers; Thermal sensors; Parylene C; chemical stimulation; microfluidic delivery; thermal flow sensor;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems, 2008. NEMS 2008. 3rd IEEE International Conference on

Conference_Location

Sanya

Print_ISBN

978-1-4244-1907-4

Electronic_ISBN

978-1-4244-1908-1

Type

conf

DOI

10.1109/NEMS.2008.4484473

Filename

4484473