Title :
Magneto-therapeutic functionalized carbon nanoparticles for interrogative medicine
Author :
Kapadia, Vishal ; Huang, Houjin ; Pierstorff, Erik ; Chen, Mark ; Ho, Dean
Author_Institution :
Dept. of Biomed. Eng., Northwestern Univ., Evanston, IL
Abstract :
Magnetic nanoparticles and carbon nanotubes have both attained a large amount of focus due to their versatile properties and numerous applications. Thus, interfacing magnetic nanoparticles with carbon nanotubes would generate a class of functional materials with broad potential towards nanoscale medicine. Here, a novel method is discussed of incorporating magnetic nanoparticles (iron oxides) onto carbon nanotubes (IONs+CNTs) as well as applying these IONs+CNTs as therapeutic strategies to promote targeted necrosis in cells which may be relevant towards directed cancer therapy, as well as antibacterial/viral applications. To determine the applicability of the IONs+CNTs, we investigated their effects on the expression of cytokines that regulate cellular stress and inflammation from in vitro RAW 264.7 macrophage cell line growth with the IONs+CNTs. In addition, we performed several characterization trials to confirm the presence of a IONs+CNTs interfacing including infrared spectroscopy and scanning electron microscopy. Moreover, we evaluated the effects of applying a magnetic field towards cells that internalized the IONs+CNTs through microscopic imagery. Furthermore, we exposed the IONs+CNTs to an external rotating magnetic field to determine its applicability to aid in directed cell death. The materials/applications realized through this study may provide an efficient method of producing IONs as well as a novel method towards directed cell death that could be implemented in both the fundamental and translational fields.
Keywords :
biomedical materials; cancer; carbon nanotubes; magnetic materials; microorganisms; nanoparticles; patient treatment; antibacterial application; carbon nanotubes; cell inflammation; cellular stress; cytokines expression; directed cancer therapy; interrogative medicine; iron oxides; macrophage cell line growth; magnetic nanoparticle; magneto-therapeutic functionalized carbon nanoparticles; microscopic imagery; necrosis target; viral application; vitro RAW 264.7; Biomedical imaging; Cancer; Carbon nanotubes; Focusing; Iron; Magnetic materials; Magnetic properties; Medical treatment; Nanoparticles; Organic materials; Carbon Nanotubes; Iron Oxide; Magnetic Spin; Nanotechnology; Necrosis; Therapeutic Nanomaterials; Water Soluble;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems, 2008. NEMS 2008. 3rd IEEE International Conference on
Conference_Location :
Sanya
Print_ISBN :
978-1-4244-1907-4
Electronic_ISBN :
978-1-4244-1908-1
DOI :
10.1109/NEMS.2008.4484514