Title :
Waveguide-capillary tube integration schemes for the characterization of nano-liter liquids at millimeter wave frequencies with record sensitivities
Author :
Stiens, Johan ; Matvejev, Vladimir ; De Tandt, C. ; Ranson, W. ; Mangelings, D. ; Willaert, R. ; De Raedt, W.
Author_Institution :
Dept. of Electron. & Inf., VUB, Brussels, Belgium
Abstract :
Progress in pharmaceutical and biotechnological research relies on the availability of a variety of analytical measurement tools. In this paper we discuss the progress on our research in the field of a novel real-time label-free, and immobilization-free integrated sensor in silicon for monitoring biological substances in nano-liter liquids flowing through a capillary tube. The performance of various sensor generations is benchmarked with water-alcohol mixtures: we demonstrate an dynamic range increase from 15 to 60 dB. A selection of measurements on biological species dissolved in liquids is presented.
Keywords :
biochemistry; biosensors; chemical sensors; dissolving; millimetre waves; molecular biophysics; organic compounds; silicon; water; waveguides; H2O; Si; analytical measurement tool; biological species; biological substance monitoring; biotechnological research; dissolvation; immobilization-free integrated sensor; millimeter wave frequency; nanoliter liquid flow characterization; pharmaceutical research; real-time label-free sensor; water-alcohol mixture; waveguide-capillary tube integration scheme; Electron tubes; Liquid waveguides; Liquids; Methanol; Proteins; Reflection; Biomolecule; capillary tube; liquids; millimeter wave; substrate integration; waveguides;
Conference_Titel :
Biomedical Wireless Technologies, Networks, and Sensing Systems (BioWireleSS), 2013 IEEE Topical Conference on
Conference_Location :
Austin, TX
Print_ISBN :
978-1-4673-2930-9
DOI :
10.1109/BioWireleSS.2013.6613674
