DocumentCode :
3251187
Title :
Low-power signal processing methodologies for implantable biosensing platforms
Author :
Croce, Robert A. ; Vaddiraju, Santhisagar ; Legassey, Allen ; Islam, Syed K. ; Papadimitrakopoulos, Fotios ; Jain, Faquir C.
Author_Institution :
Technol. Incubation Program, Biorasis, Inc., Storrs, CT, USA
fYear :
2013
fDate :
7-7 Dec. 2013
Firstpage :
1
Lastpage :
5
Abstract :
This paper presents the design and implementation of highly-miniaturized, low-power CMOS signal conditioning schemes intended for use in a totally implantable biomedical sensor platform. Due to the thrust for the development implantable biomedical sensing systems for health management and disease prevention, there exists a need for signal processing schemes which occupy very little on-chip real estate and consume negligible amounts of power. In light of this, this paper presents both a CMOS current-to-frequency converter and voltage-to-frequency converter which have been designed primarily for use in implantable biosensing platforms and applications. Such designs can be implemented in stand-alone single sensor designs, or in tandem to create multi-analyte architectures. The versatility of employing current-to-frequency as well as voltage-to-frequency signal transduction schemes presents an avenue for the integration with any electrochemical sensing element which has been fabricated in an amperometric or voltammetric fashion. Furthermore, we demonstrate the efficacy of both these circuit designs by integrating them together with high performance electrochemical implantable glucose and pH sensors. The low power consumption and miniature size of the amperometric and voltammetric signal processing units (0.25 mm2 and 18 μW / 0.045 mm2 and 122 μW, respectively) presents an ideal design for signal processing in implantable continuous metabolic monitoring devices.
Keywords :
CMOS integrated circuits; amperometric sensors; biochemistry; biosensors; diseases; lab-on-a-chip; low-power electronics; medical signal processing; pH; patient monitoring; prosthetics; sugar; voltammetry (chemical analysis); CMOS current-to-frequency converter; amperometric signal processing unit; circuit designs; disease prevention; electrochemical sensing element; health management; high performance electrochemical implantable glucose sensors; implantable biosensing platform; implantable continuous metabolic monitoring devices; low power consumption; low-power CMOS signal conditioning schemes; low-power signal processing methodologies; multianalyte architectures; on-chip real estate; pH sensors; power 122 muW; power 18 muW; stand-alone single sensor design; totally implantable biomedical sensor platform; voltage-to-frequency converter; voltage-to-frequency signal transduction schemes; voltammetric signal processing unit; Biomedical monitoring; CMOS integrated circuits; Current measurement; Educational institutions; Microelectronics; Monitoring; Sugar; CMOS circuits and systems; implantable biomedical sensors; low power signal processing schemes; low-power microelectronics;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Signal Processing in Medicine and Biology Symposium (SPMB), 2013 IEEE
Conference_Location :
Brooklyn, NY
Type :
conf
DOI :
10.1109/SPMB.2013.6736771
Filename :
6736771
Link To Document :
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