DocumentCode :
3264632
Title :
Automatic modelling of protein 3D structure Nucleoplasmin-like viral coat protein from Cucumber mosaic virus
Author :
Gomase, V.S. ; Tandale, J.P. ; Patil, S.A. ; Kale, K.V.
Author_Institution :
Coll. of Comput. Sci. & Inf. Technol., Nanded
fYear :
2006
fDate :
20-23 Dec. 2006
Firstpage :
614
Lastpage :
615
Abstract :
Automatic comparative molecular modelling of viral coat protein performs the homology modelling in different steps. Protein sequence of Capsid protein (Cucumber mosaic virus strain As) shows identify homologous proteins with known 3D structures by using PSI-BLAST i.e. it shows similarity with capsid protein from Cucumber mosaic virus (strain fny). Through analysis we got Nucleoplasmin-like viral coat protein as a potential template through a very convenient user interface for target selection. Bioinformatics software tools can reveal in formation on many aspect of protein structure and function, such as protein interaction expression pattern, surface activity, binding sites, and electrostatic potentials. Study focused on computational approach to deciphering the sequence similarity, molecular modeling and their function of coat protein of cucumber mosaic virus (strain fny). The data generated from these assay is subsequently added to a searchable database that allows potential drug targets to identify.
Keywords :
biology computing; microorganisms; molecular biophysics; proteins; sequences; solid modelling; user interfaces; 3D protein structure; automatic comparative molecular modelling; binding site; bioinformatics software tool; capsid protein sequence; cucumber mosaic virus; drug; electrostatic potential; homology modelling; nucleoplasmin-like viral coat protein; protein interaction expression pattern; surface activity; target selection; user interface; Bioinformatics; Capacitive sensors; Computer science; Databases; Diseases; Drugs; Electrostatics; Information technology; Protein engineering; Protein sequence;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Advanced Computing and Communications, 2006. ADCOM 2006. International Conference on
Conference_Location :
Surathkal
Print_ISBN :
1-4244-0716-8
Electronic_ISBN :
1-4244-0716-8
Type :
conf
DOI :
10.1109/ADCOM.2006.4289965
Filename :
4289965
Link To Document :
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