Direct formation of homogeneous DNA-probe surface on polyimide thin film by vapor deposition polymerization

Summary form only given. This paper reports on the developed method for decorating DNA-probes on the chip with desired intervals and homogeneous concentration applying the vapor deposition polymerization (VDP) technique, in which hexamethylene diisocyanate (HDI) and 3,5-diaminobenzonic acid (DBA) molecules were polymerized directly on the chip to form the polymer thin layer. The interval of the reactive carboxyl-group (-COOH) on the side-chains of DBA was controlled to become 2.0 nm by choosing another molecule having this length (HDI). The result indicates the potential of our method to form the homogeneous DNA-probe surface.