DocumentCode
3274258
Title
Prediction of beta-turn types using SVM and evolutionary information
Author
Li, Qiang ; Li, Yanda
Author_Institution
Dept. of Autom., Tsinghua Univ., Beijing, China
fYear
2005
fDate
13-16 Dec. 2005
Firstpage
453
Lastpage
456
Abstract
β-turn, a majority of tight turn which is one of the three most important structural features after α-helix and β-sheet, plays an important role in protein folding and stability. In the past three decades, many methods for predicting β-turns or β-turn types have been developed. In this paper, we perform a novel method of predicting β-turn types using support vector machine, based on evolutionary information generated by PSI-BLAST and secondary structure information produce by PSIPRED. This method is tested on a non-homologous dataset of 426 protein chains. The overall accuracy and MCC of predicting type I, II, IV, VIII and NS (no-specific) β-turn is much better than neural network recently developed by Kaur and Raghava.
Keywords
evolutionary computation; proteins; support vector machines; SVM; beta-turn prediction; evolutionary information; support vector machine; Automation; Bioinformatics; Cities and towns; Databases; Laboratories; Learning systems; Neural networks; Proteins; Stability; Support vector machines;
fLanguage
English
Publisher
ieee
Conference_Titel
Intelligent Signal Processing and Communication Systems, 2005. ISPACS 2005. Proceedings of 2005 International Symposium on
Print_ISBN
0-7803-9266-3
Type
conf
DOI
10.1109/ISPACS.2005.1595444
Filename
1595444
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