Title :
Prediction of beta-turn types using SVM and evolutionary information
Author :
Li, Qiang ; Li, Yanda
Author_Institution :
Dept. of Autom., Tsinghua Univ., Beijing, China
Abstract :
β-turn, a majority of tight turn which is one of the three most important structural features after α-helix and β-sheet, plays an important role in protein folding and stability. In the past three decades, many methods for predicting β-turns or β-turn types have been developed. In this paper, we perform a novel method of predicting β-turn types using support vector machine, based on evolutionary information generated by PSI-BLAST and secondary structure information produce by PSIPRED. This method is tested on a non-homologous dataset of 426 protein chains. The overall accuracy and MCC of predicting type I, II, IV, VIII and NS (no-specific) β-turn is much better than neural network recently developed by Kaur and Raghava.
Keywords :
evolutionary computation; proteins; support vector machines; SVM; beta-turn prediction; evolutionary information; support vector machine; Automation; Bioinformatics; Cities and towns; Databases; Laboratories; Learning systems; Neural networks; Proteins; Stability; Support vector machines;
Conference_Titel :
Intelligent Signal Processing and Communication Systems, 2005. ISPACS 2005. Proceedings of 2005 International Symposium on
Print_ISBN :
0-7803-9266-3
DOI :
10.1109/ISPACS.2005.1595444