Title :
Studying protein dynamics in aqueous solutions through linear and non-linear THz spectroscopy
Author :
Feil, Thomas ; Uzawa, Takanori ; Plaxco, Kevin W. ; Allen, S. James
Author_Institution :
Univ. of California, Santa Barbara, CA
Abstract :
Direct absorption spectroscopy is used to determine the absorption coefficient of protein solutions across the spectrum from 0.1 to 3 THz. The spectra are analyzed with respect to their dependence on solution properties, protein size and protein geometry. Besides these direct absorption measurements, a non-linear two-color experiment is developed which is sensitive solely to the chirality based contribution from proteins.
Keywords :
absorption coefficients; chirality; molecular biophysics; molecular configurations; proteins; terahertz wave spectra; absorption coefficient; chirality; frequency 0.1 THz to 3 THz; linear THz spectroscopy; nonlinear THz spectroscopy; nonlinear two-color experiment; protein dynamics; protein geometry; protein solutions; Absorption; Biomedical optical imaging; Frequency; Geometry; Large-scale systems; Nonlinear optics; Optical buffering; Optical sensors; Protein engineering; Spectroscopy;
Conference_Titel :
Infrared, Millimeter and Terahertz Waves, 2008. IRMMW-THz 2008. 33rd International Conference on
Conference_Location :
Pasadena, CA
Print_ISBN :
978-1-4244-2119-0
Electronic_ISBN :
978-1-4244-2120-6
DOI :
10.1109/ICIMW.2008.4665743
