DocumentCode :
3279788
Title :
A comparison of clinical control strategies for the hyperglycemia of injury and illness
Author :
Borrello, M.A. ; Jing Sun ; Bequette, B. Wayne
Author_Institution :
Luminous Med., Carlsbad, CA, USA
fYear :
2010
fDate :
June 30 2010-July 2 2010
Firstpage :
5149
Lastpage :
5154
Abstract :
The performances of several closed-loop algorithms for the automated regulation of blood glucose in an intensive care unit are compared in simulation studies. A nonlinear compartmental model with 15 distinct sets of patient parameter values is used to mimic the difficulties faced by an ICU treating many patients with different insulin sensitivities. A major advantage to the classical PID strategy is that the tuning parameters are a clear function of sample time, whereas other published strategies are specific to a given sample time. It is difficult to regulate extreme patients (extremely low or high insulin sensitivities) with any of the controllers with fixed-parameter control laws.
Keywords :
closed loop systems; drug delivery systems; medical control systems; medical disorders; nonlinear control systems; sugar; tuning; automated blood glucose regulation; clinical control strategy; closed-loop algorithm; hyperglycemia; illness; injury; insulin sensitivity; intensive care unit; nonlinear compartmental model; patient parameter value; patient treatment; tuning parameter; Automatic control; Blood; Diabetes; Hospitals; Injuries; Insulin; Medical treatment; Protocols; Sugar; Three-term control;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
American Control Conference (ACC), 2010
Conference_Location :
Baltimore, MD
ISSN :
0743-1619
Print_ISBN :
978-1-4244-7426-4
Type :
conf
DOI :
10.1109/ACC.2010.5530679
Filename :
5530679
Link To Document :
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