• DocumentCode
    3280382
  • Title

    Formal executable descriptions of biological systems

  • Author

    Curti, Michele ; Degano, Pierpaolo ; Prandi, Davide ; Priami, Corrado ; Quaglia, Paola ; Brodo, Linda

  • Author_Institution
    Pisa Univ., Italy
  • fYear
    2005
  • fDate
    19-22 Sept. 2005
  • Firstpage
    2
  • Lastpage
    11
  • Abstract
    The similarities between systems of living entities and systems of concurrent processes may support biological experiments in silico. Process calculi offer a formal framework to describe biological systems, as well as to analyse their behaviour, both from a qualitative and a quantitative point of view. A couple of little examples help us in showing how this can be done. We mainly focus our attention on the qualitative and quantitative aspects of the considered biological systems, and briefly illustrate which kinds of analysis are possible. We use a known stochastic calculus for the first example. We then present some statistics collected by repeatedly running the specification, that turn out to agree with those obtained by experiments in vivo. Our second example motivates a richer calculus. Its stochastic extension requires a non trivial machinery to faithfully reflect the real dynamic behaviour of biological systems.
  • Keywords
    biocomputing; process algebra; stochastic processes; biological system dynamic behaviour; concurrent process system; formal executable description; living entity system; process calculi; qualitative analysis; quantitative analysis; stochastic calculus; Bioinformatics; Biological information theory; Biological system modeling; Biological systems; Calculus; Cells (biology); Computer science; Genomics; Machinery; Proteins;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Quantitative Evaluation of Systems, 2005. Second International Conference on the
  • Print_ISBN
    0-7695-2427-3
  • Type

    conf

  • DOI
    10.1109/QEST.2005.13
  • Filename
    1595776