Title :
Formal executable descriptions of biological systems
Author :
Curti, Michele ; Degano, Pierpaolo ; Prandi, Davide ; Priami, Corrado ; Quaglia, Paola ; Brodo, Linda
Author_Institution :
Pisa Univ., Italy
Abstract :
The similarities between systems of living entities and systems of concurrent processes may support biological experiments in silico. Process calculi offer a formal framework to describe biological systems, as well as to analyse their behaviour, both from a qualitative and a quantitative point of view. A couple of little examples help us in showing how this can be done. We mainly focus our attention on the qualitative and quantitative aspects of the considered biological systems, and briefly illustrate which kinds of analysis are possible. We use a known stochastic calculus for the first example. We then present some statistics collected by repeatedly running the specification, that turn out to agree with those obtained by experiments in vivo. Our second example motivates a richer calculus. Its stochastic extension requires a non trivial machinery to faithfully reflect the real dynamic behaviour of biological systems.
Keywords :
biocomputing; process algebra; stochastic processes; biological system dynamic behaviour; concurrent process system; formal executable description; living entity system; process calculi; qualitative analysis; quantitative analysis; stochastic calculus; Bioinformatics; Biological information theory; Biological system modeling; Biological systems; Calculus; Cells (biology); Computer science; Genomics; Machinery; Proteins;
Conference_Titel :
Quantitative Evaluation of Systems, 2005. Second International Conference on the
Print_ISBN :
0-7695-2427-3
DOI :
10.1109/QEST.2005.13