Title :
A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer´s disease, amyloid beta
Author :
Noda, Minoru ; Asai, Takeshi ; Yamashita, Kaoru ; Shimanouchi, Toshinori ; Umakoshi, Hiroshi ; Okuyama, Masanori ; Kuboi, Ryouichi
Author_Institution :
Grad. Sch. of Sci. & Technol., Kyoto Inst. of Technol., Kyoto, Japan
Abstract :
Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer´s disease, amyloid ß (Aß) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aß that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
Keywords :
biosensors; bolometers; chemical sensors; diseases; microsensors; molecular biophysics; proteins; thermochemistry; Alzheimer disease causative protein; amyloid beta protein detection; amyloid fibril formation; biothermochemical sensor; liposome droplet formation; liposome droplet immobilisation; microbolometer immobilized liposome; microsensor; silicon based microbolometer; Alzheimer´s disease; Biomembranes; Biosensors; Bolometers; Detectors; Lipidomics; Proteins; Temperature; Thermal conductivity; Transistors;
Conference_Titel :
Sensors, 2009 IEEE
Conference_Location :
Christchurch
Print_ISBN :
978-1-4244-4548-6
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2009.5398264
