• DocumentCode
    328189
  • Title

    A model for the induction of LTP in the hippocampus: stimulation of presynaptic terminals and Ca2+ elevation in a postsynaptic spine

  • Author

    Ichikawa, Kazuhisa ; Okamoto, Hiroshi

  • Author_Institution
    Found. Res. Lab., Fuji Xerox Co. Ltd., Kanagawa, Japan
  • Volume
    1
  • fYear
    1993
  • fDate
    25-29 Oct. 1993
  • Firstpage
    41
  • Abstract
    The authors propose a model for [Ca2+]i elevation in spines of hippocampus, which is composed of chemical reactions of glutamate and receptor channels, and diffusion of Ca2+ ion. [Ca2+]i is dramatically increased when multiple synapses are stimulated by many impulses, while increase in [Ca2+]i is small when a single synapse is stimulated. This result indicates that stimulation of multiple synapses is required for LTP induction.
  • Keywords
    biodiffusion; biomembrane transport; brain models; neural nets; neurophysiology; Ca; Ca2+ ion diffusion; LTP induction; [Ca2+]i elevation; chemical reactions; glutamate; hippocampus; long-term potentiation; multiple synapse stimulation; postsynaptic spine; presynaptic terminal stimulation; receptor channels; Biomembranes; Circuit simulation; Equivalent circuits; Extracellular; Hippocampus; Intelligent networks; Kinetic theory; Neural networks; Numerical models; Principal component analysis;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Neural Networks, 1993. IJCNN '93-Nagoya. Proceedings of 1993 International Joint Conference on
  • Print_ISBN
    0-7803-1421-2
  • Type

    conf

  • DOI
    10.1109/IJCNN.1993.713854
  • Filename
    713854
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=328189