Title :
A model for the induction of LTP in the hippocampus: stimulation of presynaptic terminals and Ca2+ elevation in a postsynaptic spine
Author :
Ichikawa, Kazuhisa ; Okamoto, Hiroshi
Author_Institution :
Found. Res. Lab., Fuji Xerox Co. Ltd., Kanagawa, Japan
Abstract :
The authors propose a model for [Ca2+]i elevation in spines of hippocampus, which is composed of chemical reactions of glutamate and receptor channels, and diffusion of Ca2+ ion. [Ca2+]i is dramatically increased when multiple synapses are stimulated by many impulses, while increase in [Ca2+]i is small when a single synapse is stimulated. This result indicates that stimulation of multiple synapses is required for LTP induction.
Keywords :
biodiffusion; biomembrane transport; brain models; neural nets; neurophysiology; Ca; Ca2+ ion diffusion; LTP induction; [Ca2+]i elevation; chemical reactions; glutamate; hippocampus; long-term potentiation; multiple synapse stimulation; postsynaptic spine; presynaptic terminal stimulation; receptor channels; Biomembranes; Circuit simulation; Equivalent circuits; Extracellular; Hippocampus; Intelligent networks; Kinetic theory; Neural networks; Numerical models; Principal component analysis;
Conference_Titel :
Neural Networks, 1993. IJCNN '93-Nagoya. Proceedings of 1993 International Joint Conference on
Print_ISBN :
0-7803-1421-2
DOI :
10.1109/IJCNN.1993.713854
