Implantable optical sensor for continuous monitoring of various hemoglobin derivatives and tissue perfusion

A novel implantable optical sensor for continuous long-term monitoring of arterial oxygen saturation and monitoring of tissue perfusion is introduced. The photoplethysmo-graphic multi-wavelength sensor with optoelectronic components mounted onto a flexible substrate and encapsulated in biocompatible silicone is attached to well-perfused intrathoracic tissue or directly onto organ surfaces. A proof-of-principle could be shown by first measurements carried out on custom-developed artificial tissue and by in vivo finger-tip measurements as well as in a domestic pig.