Title :
Application of a neural network with a modular architecture to prediction of protein secondary structures-overlearning effects on predictions
Author :
Sasagawa, Fumiyoshi ; Tajima, Koji
Author_Institution :
Int. Inst. for Adv. Study of Social Inf. Sci., Fujitsu Labs. Ltd., Kawasaki, Japan
Abstract :
The prediction of globular protein secondary structures is studied by a neural network. The application of a neural network with a modular architecture to prediction of protein secondary structures (α-helix, β-sheet and coil) is presented. Each module is a three layer neural network. The results from the neural network with a modular architecture and with a simple three layer structure are compared. Overlearning effect is investigated in ordinary and modular neural networks. The prediction accuracy by a neural network with a modular architecture is higher than of the ordinary neural network. Furthermore, the 3, 4 and 8 state classification scheme of secondary structures are considered in the ordinary three layer neural network. The percentage of correct prediction depends on these state classification method.
Keywords :
learning (artificial intelligence); molecular biophysics; multilayer perceptrons; pattern classification; proteins; α-helix; β-sheet; coil; modular architecture; neural network; overlearning effects; protein secondary structures; state classification; three layer neural network; Amino acids; Coils; Information science; Laboratories; Neural networks; Peptides; Protein engineering; Sequences;
Conference_Titel :
Neural Networks, 1993. IJCNN '93-Nagoya. Proceedings of 1993 International Joint Conference on
Print_ISBN :
0-7803-1421-2
DOI :
10.1109/IJCNN.1993.714082