Title :
Rapid synthesis and catalytic application of biocompatible HA-Au nanoparticles
Author :
Chou, Chih-Wei ; Chang, Ko-Hsin
Author_Institution :
Dept. of Cosmeceutics, China Med. Univ., Taichung, Taiwan
Abstract :
Typically, gold nanoparticles (AuNPs) are prepared by chemical reductants that utilize excess toxic reactants, which need to be removed for biological purposes. We utilized a green method involving a simple and convenient seed-mediated growth method to prepare polymer-stabilized colloidal gold by means of an ultra-violet (UV) irradiation technique for evaluating potential effects on conjugation, catalytic performance, free radical scavenging activity and cell viability. The polymer, hyaluronic acid (HA), can act as a reductant as well as particle stabilizer for AuNPs. These HA-AuNPs were introduced and investigated as a function of gold seeds volume and HAuCl4 concentration with HA. The results obtained in the present study indicate that the HA-AuNPs have good biomedical applications in biotechnology.
Keywords :
biological techniques; biomedical materials; catalysis; gold; nanomedicine; nanoparticles; organic compounds; polymers; ultraviolet spectra; Au; biocompatible HA-Au nanoparticles; biological purposes; biomedical applications; biotechnology; catalytic application; catalytic performance; cell viability; chemical reductants; free radical scavenging activity; gold nanoparticles; gold seeds; green method; hyaluronic acid; particle stabilizer; polymer; polymer-stabilized colloidal gold; seed-mediated growth method; toxic reactants; ultra-violet irradiation technique; Absorption; Chemicals; Gold; Nanoparticles; Polymers; Radiation effects; gold nanoparticles (AuNPs); hyaluronic acid (HA); ultra-violet (UV) irradiation technique;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2011 IEEE International Conference on
Conference_Location :
Kaohsiung
Print_ISBN :
978-1-61284-775-7
DOI :
10.1109/NEMS.2011.6017526
