Title :
Design of micropillar array for cell capture
Author :
Zhou, Wenli ; Wu, Qian ; Jiang, Huanan ; Zhu, Ming
Author_Institution :
Dept. of Electron. Sci. & Technol., Huazhong Univ. of Sci. & Technol., Wuhan, China
Abstract :
Micropillar based fluidic chip is an attractive platform for cell isolation, capture and detection. This paper is focused on the design of micropillar array. Its flow situation is simulated by using finite element analysis method. The relationships between the geometry and arrangement of micropillars in the array and the distribution of fluid velocity, shear stress, dynamic pressure which have to be accorded to the cell migration and capture are studied. An optimized water drop shape is obtained for micropillar design. In addition, a silicon micropillar array is proposed to be fabricated with surface functionalization for actin capture.
Keywords :
bioMEMS; finite element analysis; lab-on-a-chip; microfluidics; actin capturing; cell capture; cell capturing; cell detection; cell isolation; cell migration; dynamic pressure distribution; finite element analysis method; fluid velocity distribution; fluidic chip; micropillar array design; shear stress distribution; silicon micropillar array; surface functionalization; water drop shape optimization; Arrays; Gold; Microfluidics; Shape; Silicon; Stress; Surface treatment; cell capture; finite element analysis; fluidic chip; micropillar array; self assembly;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2011 IEEE International Conference on
Conference_Location :
Kaohsiung
Print_ISBN :
978-1-61284-775-7
DOI :
10.1109/NEMS.2011.6017531
