Title :
A decision-theoretic model of selection modulated intra-host antigenic variation for multi-strain pathogens
Author :
Chattopadhyay, I. ; Mohinta, S. ; Ray, A.
Author_Institution :
Dept. of Mech. Eng., Pennsylvania State Univ., University Park, PA, USA
fDate :
June 30 2010-July 2 2010
Abstract :
A decision-theoretic approach to modeling the response of multi-strain pathogens to humoral defense is investigated in this paper. The reported theory of language-measure theoretic optimal control is used to compute the optimal response of the invading pathogen. The model is validated by comparison of simulation results with in-vivo observations and contrasted with prominent existing modeling approaches.
Keywords :
Markov processes; biology; decision theory; discrete event systems; diseases; formal languages; microorganisms; optimal control; decision theoretic model; discrete event system; finite Markov chain; humoral defense; in vivo observation; intrahost antigenic variation; language measure theoretic optimal control; multistrain pathogen; Capacitive sensors; Computational modeling; Genetic mutations; Immune system; In vivo; Influenza; Lattices; Optimal control; Pathogens; Vaccines; Antigenic Drift; Discrete Event Systems; Finite Markov Chains; Language Measure; Multi-strain Pathogens;
Conference_Titel :
American Control Conference (ACC), 2010
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-4244-7426-4
DOI :
10.1109/ACC.2010.5530990
