Influence of hot embossed process parameters on biodegradable polymer microstructure for drug delivery

Author

Gao, Yang ; Chen, Tianning ; Wang, Xiaopeng ; Tang, Junqiang

Author_Institution

Sch. of Mech. Eng., Xi´´an Jiaotong Univ., Xi´´an, China

fYear

2011

fDate

20-23 Feb. 2011

Firstpage

1246

Lastpage

1249

Abstract

Based on UV-LIGA technology and the hot embossing method, a novel controlled drug delivery micro-system is proposed in this paper, which is made by biodegradable polymer and suitable for subcutaneous implant releasing drug targeted. The fabricating processes about using molds and the microstructure are introduced, and then, experiments are conducted to investigate the influence of the embossing time, the pressing force and the hot embossing temperature on the quality of micro-structural formation. By the orthogonal test and analysis, the above parameters are optimized and the optimum parameters are: the hot embossing temperature at 90°C, the pressing force of 25N and the hot embossing time of 180s.

Keywords

LIGA; biodegradable materials; biomedical materials; drug delivery systems; embossing; polymers; UV-LIGA technology; biodegradable polymer microstructure; drug delivery microsystem; hot embossed process parameters; subcutaneous implant; temperature 90 degC; Drugs; Embossing; Force; Microstructure; Polymers; Pressing; drug delivery; hot embossing; microstructure; polymer; process parameters;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems (NEMS), 2011 IEEE International Conference on

Conference_Location

Kaohsiung

Print_ISBN

978-1-61284-775-7

Type

conf

DOI

10.1109/NEMS.2011.6017583

Filename

6017583