Title :
Evolutionary game theoretical approach for understanding CCR5 to CXCR4 coreceptor switch
Author :
Jing Wu ; Bewick, S. ; Ruoting Yang ; Lenaghan, S.C. ; Mingjun Zhang
Author_Institution :
Dept. of Mech., Aerosp. & Biomed. Eng., Univ. of Tennessee, Knoxville, TN, USA
fDate :
June 30 2010-July 2 2010
Abstract :
This paper shows how a game theoretical analysis can provide a model to determine the factors affecting the switch from CXCR4 coreceptor (X4) to CCR5 coreceptor (R5) in HIV-1 infected individuals. Simulations of the model predict that a persistent immune response suppresses the X4-tropic virus to a low level at first, but later increases in the immune response will trigger the switch from X4 to R5 coreceptor. In addition, we find various factors that impact the switching time.
Keywords :
cellular biophysics; game theory; microorganisms; molecular biophysics; proteins; CCR5 coreceptor; CXCR4 coreceptor; HIV-1; X4-tropic virus; game theoretical analysis; immune response; switching time; Acquired immune deficiency syndrome; Biological system modeling; Capacitive sensors; Evolution (biology); Game theory; Genetic mutations; Human immunodeficiency virus; Immune system; Switches; Viruses (medical);
Conference_Titel :
American Control Conference (ACC), 2010
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-4244-7426-4
DOI :
10.1109/ACC.2010.5531370
