Title :
Ginsenoside-Rg1 does not mitigate the effects of thimerosal on the central nervous system of the pond snail Lymnaea stagnalis
Author :
Paradis, Elizabeth ; DiCecco, John
Author_Institution :
St. Mary Acad. Bay View, Riverside, RI, USA
Abstract :
It is well known that certain forms of organic mercury (such as methylmercury) are neurotoxic. In a previous study, we found that the concentration levels at which Thimerosal, an ethylmercury-based preservative found in vaccines, showed neurotoxic effects after soaking for 15 minutes was 100 μM. In this study, we tested the same molar concentration of Thimerosal in the presence of the neuroprotective compound Ginsenoside Rg-1 (Panax ginseng). We found no significant mitigation of the effects of Thimerosal on neuronal function.
Keywords :
biomedical engineering; mercury (metal); mercury compounds; neurophysiology; organic compounds; toxicology; Lymnaea stagnalis; Panax ginseng; Thimerosal; central nervous system; ethyl mercury-based preservative; ginsenoside-Rg1; methylmercury; molar concentration; neuronal function; neuroprotective compound; neurotoxic effects; neurotoxicity; organic mercury; pond snail; thimerosal; vaccines; Biomedical engineering; Biomembranes; Central nervous system; Compounds; Microelectrodes; Neurons; Vaccines; Ginseng; Ginsenoside-Rg1; Thimerosal; neuroengineering; neuron; signal processing;
Conference_Titel :
Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-61284-827-3
DOI :
10.1109/NEBC.2011.5778577