Title :
Development of an immunocompetent human skin tissue model using three dimensional (3D) freeform fabrication
Author :
Singh, Gurtej ; Lee, Vivian ; Trasatti, John P. ; Yoo, Seung-Schik ; Dai, Guohao ; Karande, Pankaj
Author_Institution :
Chem. & Biol. Eng., Rensselaer Polytech. Inst., Troy, NY, USA
Abstract :
We report on the development of a novel in vitro, multi-compartmental, three-dimensional, Human Skin Tissue Experimental Model (HISTEM) using three-dimensional free form fabrication (3DFFF). The availability of this model is expected to positively impact the development of transdermal vaccines and immunomodulators for infectious diseases and autoimmune disorders. Our studies demonstrate the biological and structural equivalence of HISTEM with ex vivo human skin.
Keywords :
biomedical engineering; cellular biophysics; diseases; medical disorders; physiological models; skin; autoimmune disorders; cell-printing technology; ex vivo human skin; human skin tissue experimental model; immunocompetent human skin tissue model; infectious diseases; mmunomodulators; three dimensional freeform fabrication; transdermal vaccines; Biological system modeling; Humans; Immune system; In vitro; Printing; Skin; Three dimensional displays;
Conference_Titel :
Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-61284-827-3
DOI :
10.1109/NEBC.2011.5778579
