Guest editorial: computational systems biology

Systems biology and bioinformatics have become intensive research topics in the recent decade because of the emergence of high-throughput biological technologies. The generated large biological data have provided an alternative and a comprehensive way to decipher the biological systems at molecular and network levels. These research topics have attracted many leading scientists in Biology, Physics, Mathematics, Systems Science, Computer Science, Control Science and Statistics. Many computational and mathematical systems biology methods have been widely developed to meet the request for big data.