Title :
Fluid induced mechanical environment of cells during high-frequency oscillations in-vitro
Author :
Uzer, G. ; Chiang, F.P. ; Judex, S.
Author_Institution :
Stony Brook Univ., Stony Brook, NY, USA
Abstract :
Bone cells can perceive high-frequency oscillations as an anabolic signal. The oscillatory motions will generate forces not only through accelerations but also through fluid-cell interactions within the bone structure. Here, we describe a combined computational and experimental method to quantify the mechanical environment that cells are exposed to during high-frequency mechanical oscillations in-vitro. Finite element (FE) modeling determined the velocity profile of a viscous fluid in a rigid container oscillating horizontally at 60 Hz with 1g peak accelerations. Predicted peak fluid shear stresses approached 0.1Pa. When compared to FE, speckle interferometry revealed a similar fluid behavior over one cycle. The identification of fluid shear as a force concomitant to accelerations during high frequency oscillations in-vitro emphasizes that there are multiple potential mechanisms by which cells may sense these low-magnitude mechanical signals.
Keywords :
acceleration; biological fluid dynamics; bone; cellular biophysics; finite element analysis; fluid oscillations; light interferometry; shear flow; speckle; velocity measurement; anabolic signal; bone cells; finite element modeling; fluid shear; fluid-cell interactions; high-frequency oscillations; speckle interferometry; viscous fluid; Acceleration; Bones; Interferometry; Oscillators; Speckle; Viscosity;
Conference_Titel :
Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-61284-827-3
DOI :
10.1109/NEBC.2011.5778633