Title :
An image driven systems biology approach for neurodegenerative disease studies in the TSC-mTOR pathway
Author :
Beck, Dominik ; Zhou, Xiaobo ; Pham, Tuan ; Sabatini, Bernardo ; Wong, Stephen T C
Author_Institution :
Weill Med. Coll., Dept. of Radiol., Cornell Univ., Houston, TX
Abstract :
In this brief paper we present an overview of the TSC-mTOR pathway and its importance in neurodegenerative disease (ND). We illustrate the influence of ND on dendritic spine morphology. Then we discuss some details of functional gene networks (FGN) and use this information to propose an image driven systems biology approach for the construction of a FGN for ND. We conclude on its importance and the prospective outcome of our study.
Keywords :
complex networks; diseases; neurophysiology; TSC-mTOR pathway; dendritic spine morphology; functional gene networks; image driven systems biology; neurodegenerative disease; Biomedical imaging; Biomedical informatics; Biotechnology; Cancer; Cardiac disease; Cardiovascular diseases; Image analysis; Neodymium; Neoplasms; Systems biology;
Conference_Titel :
Life Science Systems and Applications Workshop, 2009. LiSSA 2009. IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4244-4292-8
Electronic_ISBN :
978-1-4244-4293-5
DOI :
10.1109/LISSA.2009.4906703
