Miniature voltage sensitive dye imaging system for in vivo experiments

Author

Park, Joon Hyuk ; Pieribone, Vincent ; Culurciello, Eugenio

Author_Institution

Dept. of Electr. Eng., Yale Univ., New Haven, CT

fYear

2009

fDate

9-10 April 2009

Firstpage

70

Lastpage

73

Abstract

Currently, there are no widely used methods of optically recording rapid electrical events over a wide cortical area in freely moving animals. This paper presents an image sensor for recording electrical activity of large regions (4-9 mm²) of the nervous tissue at high speeds (> 500 Hz) using voltage sensitive dye imaging (VSDI) in freely moving animals. Each 75 mum x 75 mum pixel consists of a photodiode of 74 mum x 34 mum and a storage capacitor of 788 fF. The image sensor has a signal-to-noise ratio of 76 dB.

Keywords

bioelectric phenomena; biomedical optical imaging; brain; dyes; fluorescence; image sensors; neurophysiology; photodiodes; cortex; freely moving animals; image sensor; nervous tissue; photodiode; rapid electrical events; storage capacitor; voltage sensitive dye imaging; Animals; Capacitors; High speed optical techniques; Image sensors; In vivo; Optical imaging; Optical recording; Optical sensors; Photodiodes; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Life Science Systems and Applications Workshop, 2009. LiSSA 2009. IEEE/NIH

Conference_Location

Bethesda, MD

Print_ISBN

978-1-4244-4292-8

Electronic_ISBN

978-1-4244-4293-5

Type

conf

DOI

10.1109/LISSA.2009.4906712

Filename

4906712