Delivery of FGF from nanofiber-microsphere composites for meniscus tissue engineering

Author

Ionescu, L.C. ; Schenker, M.L. ; Esterhai, J.E. ; Mauck, R.L.

Author_Institution

McKay Orthopedic Surg. Res. Lab., Univ. of Pennsylvania, Philadelphia, PA, USA

fYear

2011

fDate

1-3 April 2011

Firstpage

1

Lastpage

2

Abstract

A polymeric composite of electrospun PCL fibers and entrapped PLGA microspheres containing FGF was formulated for application in meniscus tissue engineering. Both in vitro and preliminary in vivo findings demonstrate that the growth factor remains bioactive within the composite and stimulates cell division upon in vitro release and tissue development after subcutaneous implantation. Ongoing work will optimize this novel delivery system and introduce additional factors to foster a regenerative environment for directed meniscus repair.

Keywords

cellular transport; electrospinning; nanocomposites; nanofibres; nanomedicine; polymer fibres; tissue engineering; FGF delivery; cell division; electrospun PCL fiber; entrapped PLGA microsphere; growth factor; meniscus tissue engineering; nanofiber-microsphere composite; polymeric composite; subcutaneous implantation; Biomedical imaging; Blood vessels; In vitro; In vivo; Maintenance engineering; Materials; Tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast

Conference_Location

Troy, NY

ISSN

2160-7001

Print_ISBN

978-1-61284-827-3

Type

conf

DOI

10.1109/NEBC.2011.5778704

Filename

5778704