Title :
Delivery of FGF from nanofiber-microsphere composites for meniscus tissue engineering
Author :
Ionescu, L.C. ; Schenker, M.L. ; Esterhai, J.E. ; Mauck, R.L.
Author_Institution :
McKay Orthopedic Surg. Res. Lab., Univ. of Pennsylvania, Philadelphia, PA, USA
Abstract :
A polymeric composite of electrospun PCL fibers and entrapped PLGA microspheres containing FGF was formulated for application in meniscus tissue engineering. Both in vitro and preliminary in vivo findings demonstrate that the growth factor remains bioactive within the composite and stimulates cell division upon in vitro release and tissue development after subcutaneous implantation. Ongoing work will optimize this novel delivery system and introduce additional factors to foster a regenerative environment for directed meniscus repair.
Keywords :
cellular transport; electrospinning; nanocomposites; nanofibres; nanomedicine; polymer fibres; tissue engineering; FGF delivery; cell division; electrospun PCL fiber; entrapped PLGA microsphere; growth factor; meniscus tissue engineering; nanofiber-microsphere composite; polymeric composite; subcutaneous implantation; Biomedical imaging; Blood vessels; In vitro; In vivo; Maintenance engineering; Materials; Tissue engineering;
Conference_Titel :
Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-61284-827-3
DOI :
10.1109/NEBC.2011.5778704
