Title :
Magnetic nanoparticles and a magnetic field for the rapid removal of device related infections
Author :
Taylor, Erik N. ; Webster, Thomas J.
Author_Institution :
Dept. of Orthopedics, Brown Univ., Providence, RI, USA
Abstract :
The purpose of this study was to develop materials and a method to kill bacteria, separating them from solution, using superparamagnetic iron oxide nanoparticles (SPION) coated with various antibacterials including iron, zinc, and silver. It was found that such coated SPION alone kill bacteria, and reduce biofilm formation (which is an important mode of antibiotic resistance in device related infections). With the aid of a magnet, these antibacterial properties could be manipulated and improved, potentially providing a new method for treating antibiotic resistant device related infections.
Keywords :
antibacterial activity; biomedical materials; iron; iron compounds; magnetic particles; microorganisms; nanobiotechnology; nanofabrication; nanoparticles; silver; superparamagnetism; zinc; FeO-Ag; FeO-Fe; FeO-Zn; antibacterial coated SPION; antibiotic resistance; antibiotic resistant device related infections; biofilm formation reduction; infection killing method; iron antibacterial coating; magnetic field; magnetic nanoparticles; rapid infection removal; silver antibacterial coating; superparamagnetic iron oxide nanoparticles; zinc antibacterial coating; Anti-bacterial; Coatings; Iron; Magnetic separation; Microorganisms; Silver;
Conference_Titel :
Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-61284-827-3
DOI :
10.1109/NEBC.2011.5778723
