Pore structure and hydration rates modulate the release of bioactive agents from degradable scaffolds

Author

Markenscoff, P. ; Zygourakis, K.

Author_Institution

Dept. of Electr. & Comput. Eng., Houston Univ., TX, USA

Volume

2

fYear

1999

fDate

36434

Abstract

A theoretical model was developed to study the degradation of highly porous scaffolds containing growth factors. The use of such bioactive agents has been proposed to induce and maintain differentiated cell function in bioartificial constructs. Simulation results showed that the total porosity of the scaffolds and the average pore size have significant effects on degradation rates, and consequently, on the release pattern of the growth factor. The release rates also depended on the erosion mechanism, with bulk erosion resulting in more uniform release rates of the growth factor

Keywords

biodiffusion; biomedical materials; cellular automata; dissolving; physiological models; polymers; porosity; porous materials; solvation; average pore size; bioactive agents release; bioartificial tissues; cellular automata; degradable polymers; degradable scaffolds; differentiated cell function; discrete iteration; dissolution automaton; erosion mechanism; growth factors; highly porous scaffolds; hydration rates; model; pore structure; solvent diffusion; total porosity; Automata; Biomedical engineering; Chemical engineering; Maintenance engineering; Medical treatment; Polymers; Shape; Solids; Thermal degradation; Wounds;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803875

Filename

803875