Title :
Bisphosphonate modified polyurethanes as cardiovascular biomaterials
Author :
Vyavahare, Narendra ; Alferiev, Ivan ; Lev, Robert J.
Author_Institution :
Dept. of Pediatrics, Children´´s Hosp. of Philadelphia, PA, USA
Abstract :
We have covalently attached bisphosphonates to commercial medical grade polyurethanes under mild conditions. Bisphosphonate modified polyether methanes show significantly diminished tendency to calcify as compared to control polyether methanes and thus are attractive candidates for synthetic heart valve applications
Keywords :
biomedical materials; cardiovascular system; polymers; prosthetics; bisphosphonate modified polyether methanes; bisphosphonate modified polyurethanes; cardiovascular biomaterials; commercial medical grade polyurethanes; control polyether methanes; mild conditions; synthetic heart valve applications; Cardiology; Glass; Head; Hospitals; Immune system; Pediatrics; Polymers; Rats; Spine; Valves;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803889
