Arteries engineered from vascular cells

Author

Niklason, L.E. ; Gao, Jinming ; Abbott, William ; Hirschi, Karen ; Houser, Stuart ; Marini, Robert ; Langer, Robert

Author_Institution

Dept. of Anesthesia & Biomed. Eng., Duke Univ., Durham, NC, USA

Volume

2

fYear

1999

fDate

36434

Abstract

A tissue engineering approach was developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue. A “biomimetic” pulsatile perfusion system was developed which mimicked some of the physical forces experienced by native arteries in vivo. Tissue engineered arteries were also made from porcine vascular cells, and were implanted in miniature swine, with patency documented up to 24 days by digital angiography

Keywords

biomimetics; blood vessels; cellular biophysics; haemorheology; muscle; arbitrary lengths; biodegradable scaffolds; biomimetic pulsatile perfusion system; endothelial cells; implanted in miniature swine; porcine vascular cells; smooth muscle cells; tissue engineered arteries; tissue engineering approach; vascular graft material; vascular tissue biopsy; Arteries; Biomedical engineering; Biopsy; Bioreactors; Hospitals; In vivo; Muscles; Pediatrics; Sliding mode control; Stress;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803902

Filename

803902