Implantation of rat islet-filled micromachined biocapsules in mice

Author

Desai, Tejal A. ; Hansford, Derek J. ; Ferrari, Mauro ; Rastellini, Cristiana

Author_Institution

Dept. of Bioeng., Illinois Univ., Chicago, IL, USA

Volume

2

fYear

1999

fDate

36434

Abstract

This study investigates whether microfabricated silicon-based biocapsules, with uniform membrane pore sizes in the tens of nanometer range, can provide immunoprotection of rat islets transplanted into a mouse model. By utilizing microfabrication technology, biocapsules are fabricated with membranes having precisely controlled and uniform pore sizes, allowing one to optimize parameters specifically for the immunoisolation of hormone-secreting cells. The study evaluates biocompatibility and short term therapeutic efficacy for implanted biocapsules

Keywords

biological tissues; biomedical materials; biomembranes; cellular transport; micromachining; porosity; surgery; Langerhans islets; cell migration; hormone-secreting cells; immunoisolation; immunoprotection; implantation in mice; microfabricated silicon-based biocapsules; mouse model; rat islet-filled micromachined biocapsules; short term therapeutic efficacy; transplanted rat islets; uniform membrane pore sizes; Adhesives; Animals; Biomembranes; Etching; Immune system; Insulin; Mice; Pancreas; Proteins; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803904

Filename

803904