Title :
Cell-mediated mineralization model for bioprosthetic heart valve tissue
Author :
Ng, Grace ; Hwang, Ned H C ; Cheung, Herman S.
Author_Institution :
Dept. of Biomed. Eng., Miami Univ., Coral Gables, FL, USA
Abstract :
Calcification is the major cause of degeneration in bioprosthetic heart valves. One possible solution to the problem is to coat the surface of the heart valve with anti-mineralization agents, which are known to inhibit soft tissue calcification, e.g. phosphocitrate and bisphosphonates. However, there are a few steps that must be performed before coating the surface of the heart valve with these agents. The focus of this paper is on these intermediate steps, which led to the design of a cell-mediated mineralization model for bioprosthetic heart valve tissue
Keywords :
biochemistry; biological tissues; cardiology; cellular biophysics; prosthetics; bioprosthetic heart valve tissue; bioprosthetic heart valves degeneration; bisphosphonates; cell-mediated mineralization model; heart valve surface coating; phosphocitrate; soft tissue calcification inhibition; Biological tissues; Biomedical engineering; Calcium; Coatings; Crystals; Heart valves; Humans; In vitro; In vivo; Mineralization;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803916
