Title :
A multichannel array-based biosensor for detecting multiple analytes
Author :
Golden, Joel P. ; Rowe, Chris A. ; Feldstein, Mark J. ; Hoffman, K. ; Cras, John ; Ligler, Frances S.
Author_Institution :
Naval Res. Lab., Washington, DC, USA
Abstract :
A multichannel array-based biosensor has been developed that utilizes the binding capability of antibodies as the recognition element and fluorescence as an indicator of the binding of the analyte under test. The sensor system uses ordinary microscope slides patterned with the recognition antibodies, a diode laser and a thermoelectrically cooled charge-coupled device to image the surface of the slide
Keywords :
CCD image sensors; biosensors; chemical sensors; fluorescence; GRIN lens array; antibody binding capability; avidin-biotin bridge; diode laser; fluorescence indicator; multichannel array-based biosensor; multiple analytes detection; recognition element; sandwich immunoassay; thermoelectrically cooled CCD; Biosensors; Diode lasers; Fluorescence; Image recognition; Microscopy; Pattern recognition; Sensor systems; Testing; Thermoelectric devices; Thermoelectricity;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803965
