The study of enhancing the cytotoxicity of antitumor drugs through electromagnetic pulses

Author

Wang, Baoyi ; Yang, Guo ; Zhang, Hong ; Chen, Haichuan ; Wang, Zishu ; Yang, Kong ; Sun, Jingru

Author_Institution

Dept. of Radio Electron., Sichuan Univ., Chengdu, China

fYear

2002

fDate

17-19 Aug. 2002

Firstpage

296

Lastpage

299

Abstract

We choose Hela cells as research object and study cytotoxicity generated by antitumor drug, cyclophosphamide, after cell electroporation caused by electromagnetic pulses. Compared the electroporation group with the contrast group, we find that the cytotoxicity of the electroporation group is enhanced greatly. This result indicates that electromagnetic pulses can enhance the cytotoxicity of antitumor drugs, which provide reliable evidences and a feasible approach for clinic treatment of tumor.

Keywords

bioelectric phenomena; biological effects of fields; biomagnetism; biomembrane transport; cellular effects of radiation; drug delivery systems; tumours; Hela cells; antitumor drugs; cell electroporation; clinic treatment; contrast group; cyclophosphamide; cytotoxicity; electromagnetic pulses; electroporation group; Biomembranes; Cells (biology); Drugs; EMP radiation effects; Educational institutions; Electrical capacitance tomography; Electromagnetic transients; Permeability; Pulse generation; Sun;

fLanguage

English

Publisher

ieee

Conference_Titel

Microwave and Millimeter Wave Technology, 2002. Proceedings. ICMMT 2002. 2002 3rd International Conference on

Print_ISBN

0-7803-7486-X

Type

conf

DOI

10.1109/ICMMT.2002.1187695

Filename

1187695