Title :
Estimation of plasma insulin from plasma glucose
Author :
Neatpisarnvanit, C. ; Boston, J.R.
Author_Institution :
Dept. of Electr. Eng., Pittsburgh Univ., PA, USA
Abstract :
Two plasma insulin estimators were developed and evaluated using simulation and human glucose-insulin data. The estimators use continuously monitored plasma glucose, and they were based on a simplified mathematical model of glucose-insulin metabolism. Estimator 2 is more robust to noise than Estimator 1, but it depends linearly on time and becomes unstable as time increases. A two-stage estimator is proposed to combine the good short-term behavior of Estimator 2 with the better long-term properties of Estimator 1
Keywords :
biochemistry; blood; patient monitoring; patient treatment; physiological models; proteins; continuously monitored plasma glucose; glucose-insulin metabolism; human glucose-insulin data; long-term properties; noise; plasma glucose; plasma insulin estimators; short-term behavior; simplified mathematical model; simulation; time dependence; two-stage estimator; Biochemistry; Equations; Humans; Insulin; Mathematical model; Plasma measurements; Plasma properties; Plasma simulation; Sugar; Testing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804160
