Title :
Computer modeling of depolarization changes induced by myocardial ischemia
Author :
Shenai, Mahesh ; Gramatikov, Boris ; Thakor, N.V.
Author_Institution :
Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
All modes of the grid were simulated. A 2D depolarization map allowed gross visualization of normal and ischemic propagation. For some significant nodes, unipolar lead signals were obtained, to simulate unipolar recordings. Maps of ischemic depolarization showed significant difference for non-ischemic map. Time-frequency decomposition using the continuous wavelet transform was performed on the unipolar signals to determine the frequency components of the superimposed irregularity. Myocardial ischemia was shown to cause frequency domain changes during depolarization
Keywords :
bioelectric potentials; diseases; electrocardiography; medical signal processing; muscle; physiological models; time-frequency analysis; wavelet transforms; 2D depolarization map; Luo-Rudy one-cell model; acidosis; anoxia; array of myocytes; computer modeling; continuous wavelet transform; depolarization changes; frequency components; frequency domain changes; gap junctions; hyperkalemia; ischemic propagation; myocardial ischemia; normal propagation; spatial domain modeling; superimposed irregularity; time-frequency decomposition; unipolar lead signals; Biological system modeling; Biology computing; Biomembranes; Continuous wavelet transforms; Frequency; Integrated circuit modeling; Ischemic pain; Myocardium; Visualization; Wavelet transforms;
Conference_Titel :
Computers in Cardiology 1998
Conference_Location :
Cleveland, OH
Print_ISBN :
0-7803-5200-9
DOI :
10.1109/CIC.1998.731798
